Gadolinium Chelate Contrast in Pregnancy: Fetal Biodistribution in the Nonhuman Primate
نویسنده
چکیده
Gravid macaques (n=12) were maintained on a control diet (14% calories from fat, n=4) or a high fat diet (36% calories from fat, n = 8). On gestational day 129, the macaques were injected with ProHance gadolinium contrast for placental imaging (equivalent to the third trimester). Gadolinium dose was varied based on maternal weight, using 0.1 mmol/kg dosing. Fetuses were delivered via cesarean section within 24 hours of maternal injection (range 19-21 hours). Gadolinium concentration in the placenta, fetal tissues (bone, liver, brain, kidney) and amniotic fluid was obtained by inductively coupled plasma mass spectrometry.
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